The Sweden international was unable to participate as his team secured a 1-1 draw against Manchester City and advanced to the fourth round of the Carabao Cup by defeating League One AFC Wimbledon this week.
Next up for Newcastle is a Saturday tea-time trip to Goodison Park to face Everton - but will their £63million forward make it?
Is Alexander Isak injured this weekend?
Alexander Isak has been suffering with a broken toe and boss Eddie Howe gave an update on the injury during his pre-Wimbledon press conference on Monday, when he ruled him out of the midweek clash.
"It was one of those situations where, if Alex could tolerate the pain, he would be fine," Howe said.
"He tolerated the pain for about 80 minutes (at Fulham) before he became aware of any feeling back in that toe. It was either he’d be out until probably after the international break initially, or he could carry on playing as normal if he could tolerate the feelings and the effects of the injury. He hasn’t been able to do that, so we’re back to the original diagnosis, I think.
"We're sort of assessing him on a daily basis because there is a chance he could be fit for Everton if everything falls into place. Of course, then we have a decision to make. Does he play in that game or do we leave him knowing that he'll be OK two weeks afterwards?"
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Howe will face the media again to preview the Everton clash on Friday morning, but all signs point to Isak not being involved, not least because he has not been included in the Sweden squad for the upcoming international break.
The Magpies head to Goodison with a host of injury issues. Defenders Sven Botman and Jamaal Lascelles are recovering from long-term knee injuries, while Callum Wilson has been sidelined with a back issue all season.
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Lewis Miley, Garang Kuol and Matt Target have also been out of late, with the club hoping their can use the international break to nurse their injured players back to full fitness.